Alex Karev is the former Chief of Surgery at Pacific Northwest General Hospital and former Head of Pediatric Surgery at Grey Sloan Memorial Hospital. He is the father of twins, Alexis and Eli, with his ex-wife and current partner, Izzie Stevens. He was also married to Jo Wilson before learning about Eli and Alexis. When Alex was seven, he had to start cleaning up his drunk and drug addict.. Grey's Anatomy brought back Izzie Stevens as the show said farewell to Justin Chambers' Alex Karev - and fans are NOT happy about it. And just like that, Dr. Alex Karev has left Grey's Anatomy.

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What happened with Izzie Stevens and Alex Karev 10 years ago? When Izzie (Katherine Heigl) discovered she had metastatic melanoma stage IV and was given only a 5% chance of survival, fans were.. That said, one Grey's Anatomy fan theory reveals the most logical way for Grey Sloan vets Izzie Stevens (Katherine Heigl) and Alex Karev (Justin Chambers) to return in season 20 and amend their characters' divisive exits. Viewers now know why Katherine Heigl left Grey's Anatomy after 5 years: the actor and series creator Shonda Rhimes didn't.